Trametinib (DMSO solvate)-抑制剂-深圳欣博盛生物科技有限公司

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Trametinib (DMSO solvate)

品牌：Cayman

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说明书

折扣/货期

货号：44750-10 mg	规格：10 mg	目录价：￥576
货号：44750-25 mg	规格：25 mg	目录价：￥925
货号：44750-5 mg	规格：5 mg	目录价：￥335
货号：44750-50 mg	规格：50 mg	目录价：￥1179

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Trametinib (DMSO solvate)

别名:

GSK1120212|JTP-74057

产品描述:

An inhibitor of MEK1 and -2; inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively); inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of COLO 320DM cells expressing both wild-type B-RAF and wild-type K-Ras (IC50 = >10,000 nM); reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day; decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day

保存温度:

-20

运输温度:

-20

预期分子量:

615.403873

产品形式:

A solid

纯度:

≥98%

CAS号:

1187431-43-1