Trilostane-抑制剂-深圳欣博盛生物科技有限公司

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Trilostane

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-T0449-M010	规格：10 mg	目录价：￥924
货号：CDX-T0449-M050	规格：50 mg	目录价：￥3696

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Trilostane

别名:

Desopan; Modrefen; Vetoryl; WIN 24,540

产品描述:

Trilostane is an inhibitor of the 3beta-HSDs (3beta-HSD1 and 3beta-HSD2 with Ki values of 0.10 and 1.60 µM, respectively) which plays a role in adrenal steroid biosynthesis. 3beta-hydroxysteroid dehydrogenase (3beta-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3beta-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3beta-HSD2 (type 2) is expressed in the adrenal gland, ovary and testis. While Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone and corticosterone levels, it is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. Trilostane has also anti-inflammatory and analgesic properties and systemic administration of trilostane directly affected peripheral and brain levels in neuroactive steroids and monoamine turnover, resulting in antidepressant activity.

宿主来源:

Synthetic

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

329.43

产品形式:

solid

产地:

瑞士