Ubiquitin-vinyl sulfone (human) (rec.) (HA)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Ubiquitin-vinyl sulfone (human) (rec.) (HA)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-PS0122-C050

规格：50 ug

目录价：￥4368

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ubiquitin-vinyl sulfone (human) (rec.) (HA)

别名:

HA-Ub-VS; HA-Ubiquitin-VS; HA-Ubiquitin-Vinyl sulfone

产品描述:

Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity and promote or prevent protein interactions. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various linkage specificities. This product consists of a fulllength human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a C-terminal warhead (Vinyl Sulfone) and an N-terminal HA-Tag. HA-Ubiquitin vinyl sulfone is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl sulfone group. It targets four of the five major DUB families: UCH (Ubiquitin c-terminal hydrolases), USP (Ubiquitin Specific Proteases), OTU (Ovarian Tumor Proteases), and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited. HA-Ubiquitin vinyl sulfone can be used for activity profiling experiments and using the HA-Tag conveniently for Immunoprecipitations in search for new or novel enzymes reacting with the c-terminal warhead.

宿主来源:

Synthetic.

产品浓度:

Lot dependent.

保存温度:

-20°C

运输温度:

Dry Ice

预期分子量:

~10kDa

产品形式:

liquid