Voxtalisib-抑制剂-深圳欣博盛生物科技有限公司

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Voxtalisib

品牌：Cayman

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说明书

折扣/货期

货号：30323-10 mg	规格：10 mg	目录价：￥2600
货号：30323-25 mg	规格：25 mg	目录价：￥5119
货号：30323-5 mg	规格：5 mg	目录价：￥1729
货号：30323-50 mg	规格：50 mg	目录价：￥8522

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Voxtalisib

别名:

SAR245409|XL765

产品描述:

A dual inhibitor of PI3K and mTORC (IC50s = 9, 110, 43, 9, 160, and 910 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTORC1, and mTORC2, respectively); is selective for these kinases over VPS34 (IC50 = 9,100 nM) and a panel of 130 additional protein kinases at 1.5 µM but does inhibit DNAPK (IC50 = 150 nM); decreases EGF-induced PIP3 production in PC3 prostate cancer cells (IC50 = 290 nM); reduces Akt and S6RP phosphorylation in the same model (IC50s = 250 and 120 nM, respectively); inhibits proliferation and colony formation of PC3 cells (IC50s = 1,800 and 270 nM, respectively); reduces tumor growth and increases survival in a GBM-39 mouse xenograft model at 30 mg/kg twice per day either alone or in combination with temozolomide

保存温度:

-20

运输温度:

-20

预期分子量:

270.2901

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

934493-76-2