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折扣/货期| 货号：60-596 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
WAS Antibody
别名:
Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
The Wiskott-Aldrich syndrome (WAS) family of proteins
share similar domain structure, and are involved in transduction of
signals from receptors on the cell surface to the actin
cytoskeleton. The presence of a number of different motifs
suggests that they are regulated by a number of different stimuli,
and interact with multiple proteins. Recent studies have
demonstrated that these proteins, directly or indirectly, associate
with the small GTPase, Cdc42, known to regulate formation of actin
filaments, and the cytoskeletal organizing complex, Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive
disease characterized by immune dysregulation and
microthrombocytopenia, and is caused by mutations in the WAS gene.
The WAS gene product is a cytoplasmic protein, expressed
exclusively in hematopoietic cells, which show signalling and
cytoskeletal abnormalities in WAS patients. A transcript variant
arising as a result of alternative promoter usage, and containing a
different 5' UTR sequence, has been described, however, its
full-length nature is not known.
Accession #:
P42768
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