官网链接
折扣/货期| 货号：20237-10 mg | 规格：10 mg | 目录价：￥3390 |
| 货号：20237-25 mg | 规格：25 mg | 目录价：￥7450 |
| 货号：20237-5 mg | 规格：5 mg | 目录价：￥1796 |
| 货号：20237-50 mg | 规格：50 mg | 目录价：￥13320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
XL388
产品描述:
An orally bioavailable and ATP-competitive inhibitor of mTOR (IC50 = 9.9 nM); selective for mTOR over a panel of more than 140 kinases, including various PI3Ks (IC50s = >3,000 nM); inhibits mTORC1 and mTORC2 in vitro (IC50s = 8 and 166 nM, respectively); induces cytotoxicity in MG-63, U2OS, and Saos-2 osteosarcoma and 786-0 kidney cancer cells and increases apoptosis in 786-0 and MG-63 cells; induces cell cycle arrest at the G1 phase and increases autophagy in MG-63 cells; reduces tumor growth in an MCF-7 breast cancer mouse xenograft model at 50 and 100 mg/kg; inhibits phosphorylation of mTORC1 and mTORC2 substrates p70S6K, S6, 4E-BP1, and Akt in MCF-7 and PC-3 xenograft tumors at 100 mg/kg; reduces tumor growth in U2OS and 786-0 mouse xenograft models at 20 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
455.5
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1251156-08-7
分子式:
C23H22FN3O4S
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