深圳欣博盛生物科技有限公司 a1

Zebrafish Cdc48 Antibody / Valosin-containing protein / Vcp
货号:RZ1323 规格:100 ug 目录价:¥7788.55
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Zebrafish Cdc48 Antibody / Valosin-containing protein / Vcp
产品描述:
Zebrafish Cdc48, also known as cell division cycle 48, is a crucial ATPase that is involved in various cellular processes including protein degradation, cell cycle regulation, and membrane dynamics. Cdc48 is part of the AAA+ ATPase family and functions as a part of the 26S proteasome pathway, where it helps to extract polyubiquitinated substrates from the proteasome or other cellular compartments for degradation. Additionally, Cdc48 plays a role in endoplasmic reticulum associated degradation (ERAD), maintaining cellular homeostasis by ensuring the removal of misfolded proteins.

Zebrafish Cdc48 is an ortholog of the human CDC48 protein, also known as p97. It shares significant sequence and functional conservation with its human counterpart, ensuring that it performs similar roles in regulating protein turnover, signaling pathways, and cell cycle progression. Like human p97, zebrafish Cdc48 is essential for the regulation of processes such as DNA repair, organelle biogenesis, and apoptosis, and its dysfunction can result in various diseases, including neurodegenerative disorders and certain cancers.

The use of a Zebrafish Cdc48 antibody is an invaluable tool for studying protein quality control mechanisms and their role in cellular stress responses. Such antibodies are essential for applications including western blot, immunohistochemistry, immunofluorescence, and ELISA. With a Zebrafish Cdc48 antibody, researchers can analyze Cdc48 expression in different tissues, study its involvement in proteostasis, and investigate how alterations in its function impact development and disease.

Currently, no isoforms of zebrafish Cdc48 have been documented, but its essential role in cellular maintenance and its conservation across species make it an important target for research. A high-quality Zebrafish Cdc48 antibody provides essential insights into cellular stress mechanisms and the regulation of the ubiquitin-proteasome system in zebrafish models.

反应种属:
Zebrafish
宿主来源:
Rabbit
实验应用:
WB, IHC-P
同种型:
Rabbit Ig
免疫原:
E. coli-derived zebrafish Cdc48 recombinant protein (amino acids D10-K512) was used as the immunogen for the Zebrafish Cdc48 antibody.
克隆性:
Polyclonal (rabbit origin)
纯化方式:
Antigen affinity chromatography
保存温度:
After reconstitution, the Zebrafish Cdc48 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
产品形式:
Antigen affinity purified
存储溶液:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
产地:
美国
在线留言
咨询类型
联系人
*
联系方式
*
单位名称
*
咨询内容
*
复制QQ号成功,请打开QQ后添加好友进行咨询