Zebrafish LC3B Antibody / MAP1LC3B-多抗-深圳欣博盛生物科技有限公司

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Zebrafish LC3B Antibody / MAP1LC3B

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F53289-0.08ML	规格：0.08 ml	目录价：￥2962
货号：F53289-0.4ML	规格：0.4 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Zebrafish LC3B Antibody / MAP1LC3B

产品描述:

Microtubule-associated proteins 1A/1B light chain 3B (Map1lc3b) is a highly conserved autophagy-related protein in zebrafish (Danio rerio), serving as a key component of the autophagosome membrane. It is the zebrafish ortholog of mammalian LC3B, which is widely used as a molecular marker for autophagosomes and autophagic activity.

Zebrafish Map1lc3b is initially synthesized as a cytosolic precursor (LC3-I), which undergoes post-translational cleavage and lipidation to form LC3-II, the autophagosome-associated form. This lipidated form binds to autophagic membranes, making Map1lc3b essential for autophagosome formation, maturation, and cargo recruitment.

In zebrafish, map1lc3b is expressed during early embryogenesis and throughout development, with increased expression observed in tissues undergoing high autophagic flux. It has become a widely used marker in transgenic zebrafish lines (e.g., Tg(CMV:map1lc3b-GFP)) for live imaging of autophagy under physiological and stress conditions, including nutrient deprivation, neurodegeneration, and toxin exposure.

The conserved role of Map1lc3b in autophagy makes it an important tool for studying cellular homeostasis, developmental processes, and disease models in zebrafish.

反应种属:

Mouse, Zebrafish

宿主来源:

Rabbit

实验应用:

WB, ELISA

同种型:

Rabbit Ig

免疫原:

This LC3B antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 16-50 amino acids from the N-terminal region of zebrafish Map1lc3b.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

Aliquot the Map1lc3b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

产品形式:

Antigen affinity purified

存储溶液:

In 1X PBS, pH 7.4, with 0.09% sodium azide

产地:

美国