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折扣/货期| 货号：RZ1320 | 规格：100 ug | 目录价：￥7788.55 |
Zebrafish Tbx5a is an ortholog of the human TBX5 protein, sharing significant sequence conservation and functional similarity. In both zebrafish and humans, Tbx5a regulates the formation of the heart's left ventricle and is involved in the proper patterning of the limbs during early development. Mutations in TBX5 in humans are associated with Holt-Oram syndrome, a disorder that leads to congenital heart defects and upper limb abnormalities. The conserved function of zebrafish Tbx5a makes it an ideal model for studying cardiac and limb development and for understanding the underlying genetic causes of congenital malformations.
The use of a Zebrafish Tbx5a antibody allows researchers to monitor the expression of Tbx5a in various developmental stages, particularly in the heart and limb tissues. These antibodies are invaluable for applications such as western blot, immunohistochemistry, and immunofluorescence, enabling detailed study of Tbx5a expression and its role in patterning and organogenesis. A Zebrafish Tbx5a antibody is also useful for assessing the effects of genetic mutations or environmental factors on heart and limb development.
Currently, no distinct isoforms of zebrafish Tbx5a have been identified, but its critical role in cardiac and limb development has been well documented. Using a high-quality Zebrafish Tbx5a antibody, researchers can explore the developmental pathways regulated by Tbx5a and gain insights into congenital diseases related to this transcription factor.
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