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折扣/货期| 货号：44976-1 mg | 规格：1 mg | 目录价：￥1996.6 |
| 货号：44976-10 mg | 规格：10 mg | 目录价：￥5989.8 |
| 货号：44976-5 mg | 规格：5 mg | 目录价：￥4489 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Zeprumetostat
别名:
SHR2554
产品描述:
An EZH2 inhibitor (IC50 = 0.87 nM for the wild-type enzyme); selective for EZH2 over a panel of 24 histone and DNA methyltransferases (IC50s = >10,000 nM for all) but also inhibits EZH1 (IC50 = 19.1 nM); inhibits EZH2Y641C, EZH2Y641F, EZH2Y641N, EZH2Y641S, and EZH2Y641G (IC50s = 16.8, 2.68, 1.79, 5.07, and 1.13 nM, respectively); reduces H3K27Me3 levels in Pfeiffer DLBCL cells (IC50 = 1.63 nM) and induces cell cycle arrest at the G1 phase and apoptosis in the same cells; reduces tumor growth in PDX mouse models of DLBCL at 60 and 120 mg/kg in combination with HBI 8000
保存温度:
-20
运输温度:
-20
预期分子量:
548.728
产品形式:
A solid
纯度:
≥98%
CAS号:
2098545-98-1
分子式:
C32H44N4O4
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