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折扣/货期| 货号：41863-1 mg | 规格：1 mg | 目录价：￥2157 |
| 货号：41863-10 mg | 规格：10 mg | 目录价：￥18304 |
| 货号：41863-25 mg | 规格：25 mg | 目录价：￥37667 |
| 货号：41863-5 mg | 规格：5 mg | 目录价：￥10238 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Zunsemetinib
别名:
ATI-450|CDD-450
产品描述:
An MK2-biased p38α MAPK inhibitor; selectively inhibits p38α MAPK-dependent activation of MK2 over p38α MAPK-dependent activation of MK5 and ATF2 by 750- and 700-fold, respectively; greater than 350-fold selective for p38α MAPK over a panel of 193 other kinases at 5 µM; reduces LPS-induced increases in the levels of mRNA encoding Il-1β in isolated mouse BMMs at 10 µM; reduces body weight loss, neutrophilia, and the number of osteoclasts at trabecular and cortical bone surfaces in a model of NOMIDc using Nlrp3fl(D301N)/+;CreER mice; enhances decreases in tumor volume and increases in survival in an autochthonous KPC murine PDAC model when used in combination with FIRINOX
保存温度:
-20
运输温度:
-20
预期分子量:
513.923586
产品形式:
A solid
纯度:
≥98%
CAS号:
1640282-42-3
分子式:
C25H22ClF2N5O3
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