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折扣/货期| 货号：AG-CR1-3599-M005 | 规格：5 mg | 目录价：￥600 |
| 货号：AG-CR1-3599-M025 | 规格：25 mg | 目录价：￥2160 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
2,5-Dimethyl-celecoxib
别名:
DMC; 2,5-Dimethylcelecoxib
产品描述:
Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
395.4
产品形式:
solid
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
457639-26-8
分子式:
C18H16F3N3O2S
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