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折扣/货期| 货号：SIH-637-50MG | 规格：50 mg | 目录价：￥1440 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
4-Octyl itaconate
别名:
4-Octyl methylenesuccinate; or n-Octyl 3-carboxy-3-butenoate
产品描述:
Neuroprotective Agent
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
242.3
产品形式:
White to off-white powder
产地:
加拿大
生产商:
Stressmarq
功能与背景:
4‑Octyl itaconate is a cell‑permeable derivative of itaconic acid that activates the neuroprotective transcription factor Nrf2 through alkylation of KEAP1¹. In neural systems, Nrf2 activation is closely associated with antioxidant defense and suppression of neuroinflammatory signaling. 4‑Octyl itaconate inhibits several regulated cell‑death pathways relevant to neurological disease, including ferroptosis²—a major contributor to neuronal and glial oxidative injury—as well as gasdermin B–mediated pyroptosis³, a key driver of neuroinflammatory cytokine release. In addition, it enhances secretion of anti‑inflammatory mediators⁴ and promotes a wound‑resolving, pro‑repair phenotype in activated macrophages⁵, suggesting potential to shift microglia and infiltrating myeloid cells toward a neuroprotective state in models of neurodegeneration or CNS injury.
纯度:
>98% (TLC); NMR (Conforms)
来源:
Snythetic
CAS号:
3133-16-2
分子式:
C13H22O4
溶解度:
May be dissolved in DMSO (25 mg/ml)
促销活动
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