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折扣/货期| 货号：SIH-301-50MG | 规格：50 mg | 目录价：￥6278.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
A-967079
别名:
(1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine
产品描述:
TRPA1 blocker
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
207.3
产品形式:
White solid
产地:
加拿大
功能与背景:
A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2).
纯度:
>98%
来源:
Synthetic
CAS号:
1170613-55-4
分子式:
C12H14FNO
溶解度:
Soluble in DMSO (25 mg/ml)
PubChem CID:
42641861
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