Acyl-CoA-binding Protein (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Acyl-CoA-binding Protein (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0197-3050	规格：3 x 50 ug	目录价：￥3360
货号：AG-40B-0197-C050	规格：50 ug	目录价：￥1680

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Acyl-CoA-binding Protein (human) (rec.) (His)

别名:

ACBP; Diazepam-binding Inhibitor; DBI; Endozepine; EP

产品描述:

Acyl-coenzyme A (CoA)-binding protein (ACBP) is an ubiquitously expressed 86 aa polypeptide that binds medium- and long-chain acyl-CoA esters with very high affinity. It plays a role as an intracellular carrier of acyl-CoA esters and regulates lipid metabolism in the cytoplasm of most cell types. In addition to its function within the cells as acyl-coenzyme A (CoA)-binding protein, ACBP also functions as secreted protein called Diazepam-Binding Inhibitor (DBI) that can interact with the benzodiazepine-binding site of the gamma-aminobutyric acid (GABA) type A receptor, GABAAR, and modulate its activity. ACBP is secreted upon induction of autophagy (energy deficiency) in different organisms including mouse and human. ACBP levels correlate with human body mass index (BMI). Increasing ACBP levels in mice triggers lipogenesis, food intake and weight gain and neutralization of ACBP increases lipolysis, reduces food intake post-starvation and causes weight loss in mice. Obese patients exhibit elevated plasma levels of ACBP, while a reduction in the ACBP mRNA and ACBP plasma protein levels is observed in these patients after an important weight loss. ACBP might be useful for the prevention or treatment of obesity and metabolic syndrome diseases.

宿主来源:

E. coli

产品浓度:

1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

12kDa (SDS-PAGE); 12kDa (Monomer by SEC)

产品形式:

solid

存储溶液: