HpARI (CCP1/2) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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HpARI (CCP1/2) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0201-3050	规格：3 x 50 ug	目录价：￥9120
货号：AG-40B-0201-C050	规格：50 ug	目录价：￥4560

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HpARI (CCP1/2) (rec.) (His)

别名:

Heligmosomoides Polygyrus Alarmin Release Inhibitor Truncated (CCP1/2); HpARI Truncation Lacking CCP3

产品描述:

HpARI is a protein secreted by the mouse parasite Heligmosomoides polygyrus. The mature protein HpARI, containing three predicted Complement Control Protein (CCP)-like modules (also known as Short Consensus Repeats (SCRs) or sushi-domains), suppresses type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. A non-natural truncation consisting of the first 2 domains of HpARI (CCP1/2) retains IL-33 and DNA binding capacity. HpARI (CCP1/2) is able to stabilize IL-33, increasing its half-life and amplifying its effects. HpARI (CCP1/2) increases IL-33 activity by protecting it from oxidation and proteolytic degradation. HpARI (CCP1/2) (rec.) (His) is a new type of reagent to study IL-33-mediated pathology in vivo.

宿主来源:

HEK 293 cells

靶标/特异性:

Binds to human and mouse IL-33.

产品浓度:

After reconstitution: 1mg/ml

保存温度:

+4°C

运输温度:

预期分子量:

~28kDa (SDS-PAGE)

产品形式: