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折扣/货期| 货号：AG-CR1-0154-M010 | 规格：10 mg | 目录价：￥660 |
| 货号：AG-CR1-0154-M050 | 规格：50 mg | 目录价：￥2760 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AdipoRon
别名:
2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
产品描述:
Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration [1, 2]. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1]. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism [1]. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1]. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet [1]. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice [1].
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
428.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
924416-43-3
分子式:
C27H28N2O3
溶解度:
Soluble in DMSO (~30mg/ml), 100% ethanol (~15mg/ml) or methanol (~10mg/ml). Insoluble in water.
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