AFAP1L2 Antibody-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

AFAP1L2 Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：5221-0.02 mg	规格：0.02 mg	目录价：￥1345.5
货号：5221-0.1 mg	规格：0.1 mg	目录价：￥6084

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

AFAP1L2 Antibody

别名:

AFAP1L2 Antibody: XB130, KIAA1914, CTB-1144G6.4, XB130, Actin filament-associated protein 1-like 2, AFAP1-like protein 2

反应种属:

Human,Mouse,Rat

宿主来源:

Rabbit

实验应用:

ELISA,WB,IHC-P,IF

同种型:

IgG

克隆性:

Polyclonal

纯化方式:

AFAP1L2 Antibody is affinity chromatography purified via peptide column.

偶联:

Unconjugated

产品浓度:

1 mg/mL

保存温度:

AFAP1L2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

AFAP1L2 Antibody is supplied in PBS containing 0.02% sodium azide.

产地:

美国

生产商:

Prosci

功能与背景:

AFAP1L2 Antibody: AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.

Accession #:

NP_001001936

您可能感兴趣的产品

sPLA2 (human Type IIA) Polyclonal Antibody - Purified IgG

货号：45805

PAD3 Polyclonal Antibody

货号：33913

Growth Hormone (rat) Polyclonal Antibody for IHC

货号：C03904.25 µl

Goat Anti-ImmunoglobulinG (mouse) Polyclonal Antibody

货号：C03757.10 ml

Goat Anti-ImmunoglobulinG (rat) Polyclonal Antibody