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折扣/货期| 货号：SIH-402-10MG | 规格：10 mg | 目录价：￥907.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AICAR
别名:
N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
产品描述:
Autophagy inducer
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
258.2
产品形式:
Off-white solid.
产地:
加拿大
功能与背景:
AICAR is an adenosine analog that when phosphorylated forms 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5'-monophosphate (ZMP) which proceeds to activate adenosine monophosphate-activated protein kinase (AMPK). This process in turn stimulates glucose uptake by skeletal muscle in an insulin-dependent manner. Autophagy is initiated by the UNC-51-like kinase 1/2 complex (ULK1 and ULK2). Under basal conditions, autophagy is negatively regulated due to the phosphorylation of ULK1 at serine-757 by mTORC1. During starvation, autophagy is positively regulated by ULK1/2 when it is phosphorylated at serine-555 and serine-777 by AMPK. Therefore, the activation of AMPK by AICAR, in turn will induce autophagy.
纯度:
>99% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
2627-69-2
分子式:
C9H14N4O5
溶解度:
Soluble to 75 mM in water and to 75 mM in DMSO.
PubChem CID:
17513
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