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折扣/货期| 货号：9653P | 规格：0.05 mg | 目录价：￥1740.375 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AIFM2 (CT) Peptide
别名:
AIMF2
实验应用:
Blocking
产品浓度:
200 ug/mL
保存温度:
Store AIFM2 (CT) Peptide at -20˚C, stable for one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
产地:
美国
生产商:
Prosci
功能与背景:
AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis
Accession #:
Q9BRQ8
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