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折扣/货期| 货号：ANC-198-020 | 规格：100 ug | 目录价：￥3010 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-CD47 (human), mAb (ANC2F6)
别名:
IAP; Integrin Associated Protein; Leukocyte Surface Antigen CD47
产品描述:
Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer.
宿主来源:
Purified from concentrated hybridoma tissue culture supernatant.
实验应用:
ELISA, FACS
靶标/特异性:
Binds to an epitope within the extracellular Ig-like domain of human CD47.
同种型:
Mouse IgG1kappa
免疫原:
Recombinant human CD47 (extracellular Ig domain).
克隆号:
ANC2F6
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5mg/ml Gentamicin sulfate.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
上一个:anti-CD46 (human), mAb (169-1-E4.3) (preservative free)
下一个:anti-CD47 (human), mAb (ANC2F6) (Biotin)
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