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折扣/货期| 货号：SKT-123-96 | 规格：96 well | 目录价：￥9949.5 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Alpha B Crystallin ELISA Kit
别名:
AACRYA ELISA Kit, CRYA2 ELISA Kit, CRYAB ELISA Kit, CTPP2 ELISA Kit, HSPB5 ELISA Kit, NY Ren 27 antigen ELISA Kit, alpha crystallin B ELISA Kit
产品描述:
Colorimetric detection of alpha B Crystallin
反应种属:
Human
保存温度:
4ºC and -20ºC
运输温度:
Blue Ice
产地:
加拿大
功能与背景:
The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. alpha and beta families are further divided into acidic and basic groups (alpha-A and alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
灵敏度:
0.009 ng/ml
检测范围:
0.352 - 22.5 ng/ml
检测方法:
Colorimetric Assay
样本类型:
Cell Lysates | Tissue | Serum
产品特点:
30 minutes
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