alpha-Cyano-4-hydroxycinnamic acid-抑制剂-深圳欣博盛生物科技有限公司

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alpha-Cyano-4-hydroxycinnamic acid

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3686-G001

规格：1 g

目录价：￥540

产品详情

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产品名称:

alpha-Cyano-4-hydroxycinnamic acid

别名:

alpha-Cyano-4-hydroxycinnamate; alpha-CCA; 4-HCCA; CHCA; NSC173138

产品描述:

Specific monocarboxylate transporter (MCT) inhibitor. Inhibits mitochondrial lactate and pyruvate transport. Decreases glycolysis. Useful agent for immunometabolism research. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration and invasion. Blocks lactate efflux from glioma cells and sensitizes cells to irradiation. Highly malignant tumors rely heavily on aerobic glycolysis (metabolism of glucose to lactic acid even under presence of oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from apoptosis. Inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors. Common organic matrix-assisted laser desorption/ionization (MALDI) matrix.

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

189.2

产品形式:

solid

产地:

瑞士

纯度:

>98%