GSK2837808A-抑制剂-深圳欣博盛生物科技有限公司

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GSK2837808A

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3685-M001	规格：1 mg	目录价：￥600
货号：AG-CR1-3685-M005	规格：5 mg	目录价：￥2280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GSK2837808A

别名:

3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid

产品描述:

Potent and selective cell permeable inhibitor of lactate dehydrogenase A (LDHA) (IC50 values are 2.6 and 43 nM for LDHA and LDHB, respectively). Decreases glycolysis. Useful agent for immunometabolism research. Exhibits antitumoral activity. Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Inhibits transcription of histone 2B (H2B) gene in HCT116 and NCM460 cells. Lactate dehydrogenase A (LDHA) is an important enzyme involved in fermentative glycolysis, important in tumor initiation and metabolism. Cancer cells rely on increased glycolysis resulting in increased lactate production in addition to aerobic respiration in the mitochondria, even under normal oxygen concentrations (a process known as the Warburg effect). This renders LDHA a promising molecular target for the treatment of various cancers.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

649.6

产品形式:

solid

产地:

瑞士

纯度:

>98%