Alpha Synuclein Antibody-单抗-深圳欣博盛生物科技有限公司

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Alpha Synuclein Antibody

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-530D

规格：100 µg

目录价：￥4246.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Alpha Synuclein Antibody

别名:

Alpha Synuclein Antibody, Non-A beta component of AD amyloid Antibody, Non-A4 component of amyloid precursor Antibody, NACP Antibody, SNCA Antibody, PARK1 Antibody, PARK 1 Antibody, alphaSYN Antibody, PARK 4 antibody, PARK4 antibody, Parkinson disease familial 1 antibody, Parkinson disease (autosomal dominant, Lewy body) 4 antibody, SYN antibody

产品描述:

Mouse Anti-Human Alpha Synuclein Monoclonal IgG1

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | DB | ICC/IF | ELISA

靶标/特异性:

Binds within the 81-130 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~30 kDa is a dimer.

同种型:

IgG1

推荐稀释度:

WB (1:1000); DB (1:1000); ICC/IF (1:100); ELISA (1:1000); optimal dilutions for assays should be determined by the user.

免疫原:

Human alpha synuclein monomer

免疫原种属:

Human

克隆性:

Monoclonal

克隆号:

3C11

纯化方式:

Protein G Purified

偶联:

Unconjugated

产品浓度:

1 mg/ml

保存温度:

-20ºC

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Accession #:

NP_000336.1