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折扣/货期| 货号：71670-10 mg | 规格：10 mg | 目录价：￥1288 |
| 货号：71670-100 mg | 规格：100 mg | 目录价：￥9310 |
| 货号：71670-5 mg | 规格：5 mg | 目录价：￥686 |
| 货号：71670-50 mg | 规格：50 mg | 目录价：￥4984 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AM251
产品描述:
A CB1 receptor antagonist; binds to CB1 receptors in rat forebrain membrane preparations (Ki = 7.5 nM); selective over CB2 receptors (Ki = 2,290 nM for mouse spleen membrane preparations); inhibits CP 55,940-induced GTPγS binding in HEK293 cells expressing human CB1 receptors (EC50 = 8 nM); decreases immobility time in the forced swim test in wild-type but not CB1 receptor-deficient mice at 10 mg/kg; reduces fasting-induced food intake and body weight gain in mice at 30 mg/kg; induces GTPγS binding in HEK293 cells expressing the orphan receptor GPR55 (EC50 = 39 nM); potentiates GABA-induced GABAA receptor currents (EC50 = 0.4 µM); prevents TGF-β1-induced EMT, inhibits SMAD2/3 and p38 MAPK activation, and reduces the expression of EMT-related transcription factors in HK-2 renal tubule epithelial cells; induces cell cycle arrest at the G2/M phase and apoptosis in A375 human melanoma cells
保存温度:
-20
运输温度:
-20
预期分子量:
555.2
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
183232-66-8
分子式:
C22H21Cl2IN4O
促销活动
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