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折扣/货期| 货号：AG-40A-0075-C010 | 规格：10 ug | 目录价：￥1920 |
| 货号：AG-40A-0075-C050 | 规格：50 ug | 目录价：￥3780 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ANGPTL4 (mouse) (rec.)
别名:
Angiopoietin-like Protein 4; FIAF; Fasting-induced Adipose Factor; HFARP; Hepatic Fibrinogen/Angiopoietin-related Protein
产品描述:
ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
宿主来源:
COS-7 cells
产品浓度:
0.5mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~50kDa (SDS-PAGE)
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Activates ERK phosphorylation in THP-1 cells.
内毒素水平:
<0.1EU/µg purified protein (LAL test; Lonza).
促销活动
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