anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)-单抗-深圳欣博盛生物科技有限公司

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anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-27B-6003PF-C100

规格：100 ug

目录价：￥4800

产品详情

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产品名称:

anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)

别名:

TNF-alpha-converting Enzyme; Disintegrin and Metalloproteinase Domain-containing Protein 17; CD156b

产品描述:

ADAM17 (Disintegrin and metalloproteinase domain-containing protein 17), also called TACE (Tumor necrosis factor-alpha-converting enzyme) is the prototype of the ADAM family of ectodomain shedding proteases (sheddase). ADAM17 is understood to be involved in the processing of TNF-alpha at the surface of the cell and from within the intracellular membranes of the trans-Golgi network. This process involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha) and is of known physiological importance. ADAM17 is responsible for the processing of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands and enzymes, including cleaving epidermal growth factor receptor (EGFR) ligands and extracellular Notch1. The proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of inflammatory diseases (e.g. rheumatoid arthritis) or inflammation associated cancer.

宿主来源:

E. coli

实验应用:

FUNC, FUNC (Blocking)

靶标/特异性:

Recognizes the catalytic and non-catalytic domain of human ADAM17 (TACE) through its variable light (VL) domain and variable heavy (VH) domain, respectively. Does not bind recombinant mouse ADAM17 ectodomain.

同种型:

Human Fab fragment, kappa, His-tagged

免疫原:

Recombinant human ADAM17 (TACE) ectodomain tagged to biotin.

克隆号:

D1(A12)

偶联:

Preservative Free

产品浓度:

1mg/ml

保存温度:

+4°C