anti-APRIL, mAb (Heaty-1)-单抗-深圳欣博盛生物科技有限公司

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anti-APRIL, mAb (Heaty-1)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0082-C100

规格：100 ug

目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-APRIL, mAb (Heaty-1)

别名:

A Proliferation Inducing Ligand; Tumor Necrosis Factor Ligand Superfamily Member 13; TNFSF13; TALL-2; CD256

产品描述:

APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, IP

靶标/特异性:

Recognizes mouse and human recombinant and endogenous APRIL.

同种型:

Mouse IgG2b

免疫原:

Recombinant mouse APRIL.

克隆号:

Heaty-1