anti-FADD (human), mAb (1C4) (Biotin)-单抗-深圳欣博盛生物科技有限公司

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anti-FADD (human), mAb (1C4) (Biotin)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0080B-C100

规格：100 ug

目录价：￥3120

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-FADD (human), mAb (1C4) (Biotin)

别名:

FAS-associated Death Domain Protein; Growth-inhibiting Gene 3 Protein; Mediator of Receptor Induced Toxicity; MORT1

产品描述:

FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, IP, WB

靶标/特异性:

Recognizes the C-terminus of human FADD only in its unphosphorylated form.

同种型:

Mouse IgG1

免疫原:

Recombinant human FADD.

克隆号:

1C4