anti-AR (C-terminal) (human), Rabbit Monoclonal (RM255)-单抗-深圳欣博盛生物科技有限公司

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anti-AR (C-terminal) (human), Rabbit Monoclonal (RM255)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1136-00-R100

规格：100 ul

目录价：￥6258

产品详情

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产品名称:

anti-AR (C-terminal) (human), Rabbit Monoclonal (RM255)

别名:

Androgen Receptor; Dihydrotestosterone Receptor; Nuclear Receptor Subfamily 3 Group C Member 4

产品描述:

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

RM255 reacts to human androgen receptor (C-terminal).

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the C-terminus of human Androgen Receptor.

克隆号:

RM255