anti-Cardif (human), mAb (Adri-1) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-Cardif (human), mAb (Adri-1) (25 ug)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0004-C100	规格：100 ug	目录价：￥4320
货号：AG-20B-0004-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Cardif (human), mAb (Adri-1) (25 ug)

别名:

CARD Adapter Inducing Interferon-beta; IPS-1; MAVS; Mitochondrial Antiviral Signaling Protein; VISA; Virus-induced Signaling Adapter; Interferon-beta Promoter Stimulator Protein 1

产品描述:

RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ICC, IHC, IP, WB

靶标/特异性:

Recognizes human Cardif.

同种型:

Mouse IgG2b

免疫原:

Recombinant human Cardif (aa 160-450).

克隆号:

Adri-1