anti-CD27 (human), Rabbit Monoclonal (RM501)-单抗-深圳欣博盛生物科技有限公司

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anti-CD27 (human), Rabbit Monoclonal (RM501)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1393-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-CD27 (human), Rabbit Monoclonal (RM501)

别名:

T Cell Activation Antigen CD27; T14; TNFRSF7; Tumor Necrosis Factor Receptor Superfamily Member 7; S152

产品描述:

CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis. The expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and immunosuppression.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

RM501 reacts to human CD27 (TNFRSF7).

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to residues near the C-terminus of human CD27.

克隆号:

RM501