anti-Cleaved Caspase 8 (human), Rabbit Monoclonal (RM442)-单抗-深圳欣博盛生物科技有限公司

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anti-Cleaved Caspase 8 (human), Rabbit Monoclonal (RM442)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1333-00-R100

规格：100 ul

目录价：￥5726

产品详情

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产品名称:

anti-Cleaved Caspase 8 (human), Rabbit Monoclonal (RM442)

别名:

Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease

产品描述:

Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

宿主来源:

Rabbit

实验应用:

靶标/特异性:

This antibody reacts to human cleaved Caspase 8 only.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the C-terminus of human caspase 8.

克隆号:

RM442

产品浓度: