anti-Granzyme B (human), Rabbit Monoclonal (RM441)-单抗-深圳欣博盛生物科技有限公司

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anti-Granzyme B (human), Rabbit Monoclonal (RM441)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1332-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Granzyme B (human), Rabbit Monoclonal (RM441)

别名:

CGL1; Cathepsin G-like 1; CTLA-1; Fragmentin-2

产品描述:

Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. Shown to activate caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

宿主来源:

Rabbit

实验应用:

IHC

靶标/特异性:

This antibody reacts to human Granzyme B.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the C-terminus of human Granzyme B.

克隆号:

RM441