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折扣/货期| 货号：REV-31-1332-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-Granzyme B (human), Rabbit Monoclonal (RM441)
别名:
CGL1; Cathepsin G-like 1; CTLA-1; Fragmentin-2
产品描述:
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. Shown to activate caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
宿主来源:
Rabbit
实验应用:
IHC
靶标/特异性:
This antibody reacts to human Granzyme B.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to the C-terminus of human Granzyme B.
克隆号:
RM441
产品浓度:
N/A
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
促销活动
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