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折扣/货期| 货号：REV-31-1397-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-DNA-PKcs (human), Rabbit Monoclonal (RM505)
别名:
DNA-dependent Protein Kinase Catalytic Subunit; PRKDC; DNPK1; p460
产品描述:
DNA-dependent protein kinase (DNA-PK) is an important factor in the repair of double-stranded breaks in DNA. Cells lacking DNA-PK or in which DNA-PK is inhibited fail to show proper nonhomologous end-joining (NHEJ). DNA-PK is composed of two DNA-binding subunits (Ku70 and Ku86) and one 450 kDa catalytic subunit (DNA-PKcs). It is thought that a heterodimer of Ku70 and Ku86 binds to double-stranded DNA broken ends before DNA-PKcs binds and is activated. Activated DNA-PKcs is a serine/threonine kinase that has been shown to phosphorylate a number of proteins in vitro, including p53, transcription factors, RNA polymerase, and Ku70/Ku86. DNA-PKcs autophosphorylation at multiple sites, including Thr2609 and Ser2056, results in an inactivation of DNA-PK kinase activity and NHEJ ability and may play a role in disassembly of the DNA repair machinery. Autophosphorylation at Thr2609 has also been shown to be required for DNA-PK-mediated double-strand break repair, and phosphorylated DNA-PK co-localizes with H2A.X and 53BP1 at sites of DNA damage. Phosphorylation at Ser2056 occurs in response to double-stranded DNA breaks and ATM activation. Higher expression of DNA-PK has been determined in several cancer tissues making it an interesting biomarker.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
This antibody reacts to human DNA-PKcs.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to the C-terminus of human DNA-PKcs.
克隆号:
RM505
产品浓度:
N/A
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
上一个:anti-GCDFP-15 (human), Rabbit Monoclonal (RM504)
下一个:anti-UP2 (Uroplakin-2) (human), Rabbit Monoclonal (RM507)
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