anti-E-Cadherin (human), Rabbit Monoclonal (RM244)-单抗-深圳欣博盛生物科技有限公司

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anti-E-Cadherin (human), Rabbit Monoclonal (RM244)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1123-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-E-Cadherin (human), Rabbit Monoclonal (RM244)

别名:

CDH1; CAM 120/80; CD324

产品描述:

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development. The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. E-Cadherin (epithelial cadherin) is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human E-cadherin (Cadherin-1).

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to Cadherin-1.

克隆号:

RM244