anti-Galectin-9 (human), Rabbit Monoclonal (RM499)-单抗-深圳欣博盛生物科技有限公司

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anti-Galectin-9 (human), Rabbit Monoclonal (RM499)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1391-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Galectin-9 (human), Rabbit Monoclonal (RM499)

别名:

Gal-9; Ecalectin; Tumor Antigen HOM-HD-21; TIM-3 Ligand; T Cell Immunoglobulin and Mucin Domain-containing Protein 3 Ligand

产品描述:

Galectin-9 (Gal-9), a beta-galactoside-binding protein, primarily plays an immunosuppressive role in the tumor microenvironment, via binding with several cell surface receptors expressed on immune cells. Although Gal-9 was initially identified as a ligand for T-cell immunoglobulin and mucin domain–containing molecule 3 (TIM-3) in the induction of T-cell death, it also binds to other immunoregulatory receptors. For instance, Gal-9 binding to the innate receptor dectin-1 promotes M2 polarization of macrophages that suppresses antitumor immune responses. Gal-9 has also been shown to promote the differentiation of regulatory T cells (Tregs) through interaction with cluster of differentiation 44 (CD44) and drive the expansion of Tregs through binding with death receptor 3. The aberrantly high expression of Gal-9 in a range of cancers suggests that Gal-9 could be significant both as a biomarker and a therapeutic target.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human Galectin-9.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the N-terminus of human Galectin-9 (Gal-9).

克隆号:

RM499