anti-LAIR1 (human), Rabbit Monoclonal (RM498)-单抗-深圳欣博盛生物科技有限公司

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anti-LAIR1 (human), Rabbit Monoclonal (RM498)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1390-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-LAIR1 (human), Rabbit Monoclonal (RM498)

别名:

Leukocyte-associated Immunoglobulin-like Receptor 1; CD305

产品描述:

LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on the cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in the recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. LAIR1 plays a role in immune response homeostasis, and extracellular matrix remodeling and it is overexpressed in many high-grade cancers.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human LAIR1.

同种型:

Rabbit IgG

免疫原:

Recombinant extracellular domain of human LAIR1.

克隆号:

RM498