anti-gp41 (HIV), mAb (rec.) (A2)-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

anti-gp41 (HIV), mAb (rec.) (A2)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-27B-6323-C050

规格：50 ug

目录价：￥3492

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-gp41 (HIV), mAb (rec.) (A2)

别名:

Glycoprotein 41; Envelope Protein gp41, HIV; HIV Transmembrane Protein gp41; HTLV-III gp41

产品描述:

HIV-1 Env consists of two subunits: the surface-exposed glycoprotein gp120, which contains the receptor (CD4) and coreceptor (CCR5 or CXCR4) binding sites, and the transmembrane subunit gp41, which is critical for virus-cell membrane fusion. Sequential binding of HIV-1 to its receptor and coreceptor are the first steps critical for viral entry, whereby CD4 binding triggers a series of conformational changes in Env involving both gp120 and gp41. In gp120, CD4 binding induces rearrangement of the variable loops V1/V2 and formation of the bridging sheet, which allows for repositioning of the V3 loop to facilitate coreceptor binding. In gp41, CD4 binding triggers exposure of the buried N-terminal HR1 domain and its formation into a trimeric coiled-coil structure. Upon receptor and coreceptor binding, the fusion peptide in gp41 is inserted into the cell membrane and the HR1 and HR2 regions rearrange to form the six-helix bundle, which is critical for creation of the fusion pore to enable membrane fusion and efficient viral entry. The antibody clone A2 was found to specifically target the pocket-binding domain of gp41 CHR when CHRs maintain in the trimer conformation.

宿主来源:

Protein A purified from HEK293 cell culture supernatant.

实验应用:

ELISA, FACS, IP

靶标/特异性:

Recognizes gp41 from HIV. Targets the pocket-binding domain of gp41 CHR when CHRs maintain in the trimer conformation.

同种型:

Human IgG1

免疫原:

Lectin-purified gp140 (from ADA.C1 strain).

克隆号:

产品浓度: