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折扣/货期| 货号：REV-31-1145-00-R100 | 规格：100 ul | 目录价：￥5726 |
| 货号：REV-31-1145-00-R400 | 规格：400 ul | 目录价：￥13916 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263)
别名:
H3.3 G34W
产品描述:
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 has three main variants, H3.1 and H3.2, which are deposited in chromatin only during DNA replication and H3.3, which is replication independent and is found primarily in the regions of active transcription and heterochromatin. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. Recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation. All identified histone mutations (including H3K4M, H3K9M, H3K27M, H3K36M, and H3G34V/R/W) result in amino acid substitution at/near a lysine residue that is a target of methylation.
宿主来源:
Rabbit
实验应用:
ELISA, ICC, IHC, WB
靶标/特异性:
This antibody reacts to the Histone H3.3 G34W mutant. No cross reactivity with wild type Histone H3.3.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to Histone H3.3 G34W mutant.
克隆号:
RM263
产品浓度:
N/A
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
上一个:anti-p16INK4a (human), Rabbit Monoclonal (RM267)
下一个:anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263) (Biotin)
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