官网链接
折扣/货期| 货号：AG-25A-0032-C100 | 规格：100 ug | 目录价：￥3600 |
| 货号：AG-25A-0032-TRIAL | 规格：25 ug | 目录价：￥1620 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-IDO1 (mouse), pAb (25 ug)
别名:
Indoleamine 2,3-dioxygenase 1; IDO; INDO
产品描述:
IDO1 is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO1 protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system’s ability to destroy pathogens. By reducing the number of effector T cells, IDO1 overexpression prevents the immune system from effectively destroying cancer cells. IDO1 overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung cancer. Physiological IDO1 activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
宿主来源:
Rabbit
实验应用:
ELISA, ICC, IHC, WB
靶标/特异性:
Recognizes mouse IDO1. Detects a band of ~45kDa by Western blot.
免疫原:
Recombinant mouse IDO1.
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
产地:
瑞士
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