anti-IL-1alpha (p18) (mouse), mAb (Teo-1)-单抗-深圳欣博盛生物科技有限公司

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anti-IL-1alpha (p18) (mouse), mAb (Teo-1)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0064-C100

规格：100 ug

目录价：￥1800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-IL-1alpha (p18) (mouse), mAb (Teo-1)

别名:

Interleukin-1alpha IL-1alpha

产品描述:

The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, WB

靶标/特异性:

Recognizes mouse IL-1alpha p18 cleaved and full-length fragments.

同种型:

Mouse IgG

免疫原:

Recombinant mouse mature IL-1alpha.

克隆号:

Teo-1