anti-alpha-Tubulin (acetylated), mAb (TEU318)-单抗-深圳欣博盛生物科技有限公司

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anti-alpha-Tubulin (acetylated), mAb (TEU318)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0068-C100

规格：100 ug

目录价：￥3840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-alpha-Tubulin (acetylated), mAb (TEU318)

产品描述:

Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Tubulin acetylation was discovered on K40 of flagellar alpha-tubulin in Chlamydomonas reinhardtii and is generally enriched on stable microtubules in cells. It is located on the microtubule lumenal surface. As a result of its localization at the inner face of microtubules, K40 acetylation might rather affect the binding of microtubule inner proteins, a poorly characterized family of proteins. Functional experiments in cells have further suggested that K40 acetylation regulates intracellular transport by regulating the traffic of kinesin motors probably by indirect mechanisms. Acetyltransferase alpha-Tat1 (or Mec-17) specifically acetylate alpha-tubulin K40. Acetylation of tubulin by alpha-Tat1 accumulates selectively in stable, long-lived microtubules thus explaining the link between this posttranslational modication and stable microtubules in cells. However, the direct cellular function of K40 acetylation on microtubules is still unclear.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ICC, WB

靶标/特异性:

Detects K40 acetylation of alpha-tubulin; signal specifically increased by modification with tubulin acetyl transferase alpha-TAT1.

同种型:

Mouse IgG1

免疫原:

Tubulin of the Ciliate Euplotes eluted from the 55kDa band of SDS gel.

克隆号:

TEU318