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折扣/货期| 货号：AG-27B-0019-C100 | 规格：100 ug | 目录价：￥4800 |
| 货号：AG-27B-0019-TRIAL | 规格：25 ug | 目录价：￥1740 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-LRP5/6, mAb (rec.) (Heldy-1-4) (25 ug)
别名:
Low-density Lipoprotein Receptor-related Protein 5; LRP-5; Low-density Lipoprotein Receptor-related Protein 6; LRP-6
产品描述:
Wnt/beta-catenin signaling acts as a regulator of tissue development and homeostasis. Wnt ligands bind to a member of the Frizzled family of seven-transmembrane proteins and to either highly homologous low-density lipoprotein related receptors 5 (LRP5) or LRP6. Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptor (LDLR) family. LRP5 and LRP6 are expressed in most human tissues and is composed of three distinctive cell-surface protein domains, including (1) LDL receptor (LDLR) type A repeats; (2) an epidermal growth factor (EGF)-like domain; and (3) a YWTD (Tyr-Trp-Thr-Asp)-type beta propeller domain. LRP6 is inhibited by the Dickkopf protein Dkk1 bound to their partners Kremen. Sclerotin also acts as an inhibitor of LRP5/6 through LRP4. LRP6 is involved in cell differentiation, proliferation and migration during embryonic development and in the pathogenesis of different cancer types. LRP6 plays a major role in metabolic regulation, specifically in the nutrient-sensing pathway. Patients carrying an LRP6 mutation exhibit high serum LDL cholesterol and triglycerides, hypertension, high fasting blood glucose levels, a prevalence of diabetes and low bone density. LRP6 mutations have also been associated with diseases such as Alzheimer's and degenerative joint diseases. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density and plays a role in osteoporosis. LRP5 is aso involved in vitreoretinopathy.
宿主来源:
Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
实验应用:
FACS
靶标/特异性:
Recognizes human and mouse LRP5 & LRP6.
同种型:
Human IgG2lambda.
免疫原:
Recombinant mouse LRP6.
克隆号:
Heldy-1-4
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 10% glycerol.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
上一个:anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative free) (25 ug)
下一个:anti-Netrin-1 (human), mAb (rec.) (H4) (preservative free) (25 ug)
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