| 货号:AG-20B-0045-C100 | 规格:100 ug | 目录价:¥4680 |
| 货号:AG-20B-0045-TRIAL | 规格:25 ug | 目录价:¥1740 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
anti-NAIP1/2/5 (mouse), mAb (Naipa-1) (25 ug)
别名:
Neuronal Apoptosis Inhibitory Protein 1, 2, 5; Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e; Birc 1a, 1b, 1e
产品描述:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
宿主来源:
Purified from concentrated hybridoma tissue culture supernatant.
实验应用:
WB
靶标/特异性:
Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.
同种型:
Mouse IgG2bkappa
免疫原:
Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).
克隆号:
Naipa-1
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
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