anti-NF-kB (p65), pAb-多抗-深圳欣博盛生物科技有限公司

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anti-NF-kB (p65), pAb

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-25T-0004-R100

规格：100 ul

目录价：￥2520

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-NF-kB (p65), pAb

别名:

Nuclear Factor NF-kappaB p65 Subunit; Transcription Factor p65; RELA

产品描述:

NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappaB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappaB complex.

宿主来源:

Rabbit

实验应用:

ICC, IP, WB

靶标/特异性:

Recognizes human and mouse NF-kappaB (p65 subunit).

免疫原:

Recombinant human NF-kappaB (p65 subunit).

保存温度:

+4°C

运输温度:

产品形式: