anti-NLRC3 (mouse), mAb (Eowyn-1) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-NLRC3 (mouse), mAb (Eowyn-1) (25 ug)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0067-C100	规格：100 ug	目录价：￥4800
货号：AG-20B-0067-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-NLRC3 (mouse), mAb (Eowyn-1) (25 ug)

别名:

NOD3; Nucleotide-binding Oligomerization Protein 3; CARD15-like Protein; Caterpiller Protein 16.2; CLR16.2

产品描述:

The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

靶标/特异性:

Detects overexpressed mouse NLRC3. Doest not detect human NLRC3. Although NLRC3 (mouse), mAb (Eowyn-1) is strong and specific (see figure), the endogenous protein has not been detected yet with this antibody (using NLRC3 KO versus WT immune cells). NLRC3 protein is probably expressed at very low levels or its translation / stability is triggered by stimuli still to be discovered .

同种型:

Mouse IgG1

免疫原:

Recombinant mouse NLRC3 (card domain).

克隆号:

Eowyn-1

产品浓度:

1mg/ml

保存温度:

+4°C

运输温度:

产品形式: