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折扣/货期| 货号：AG-25B-0038-C100 | 规格：100 ug | 目录价：￥2400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-NLRC5 (mouse), pAb (IN113)
别名:
NOD-like Receptor Family CARD Domain Containing 5; Caterpiller Protein 16.1; NOD4; Nucleotide-binding Oligomerization Domain Protein 4
产品描述:
Major histocompatibility complex class I molecules are expressed in all nucleated cells, whereas MHC class II molecules are mostly expressed in hematopoietic cells. The tight regulation of both MHC class I and class II molecules is crucial for eliciting an appropriate immune response. The MHC class II and class I molecule regulation is controlled by class II MHC transactivator (CIITA) and by NLR family caspase recruitment domain-containing 5 (NLRC5), respectively. NOD-like receptor family CARD domain containing 5 (NLRC5) is the largest member of the NOD-like receptors (NLRs) family. As all NLR-family members, NLRC5 shares a similar protein structure consisting of three main domains: a variable N-terminal protein-interaction domain, a central Nucleotide-Binding Domain (NBD) and a C-terminal stretch consisting of Leucine Rich Repeats (LRRs). NLRC5 contains between its CARD and NBD domain a bipartite-type nuclear localization signal (NLS), allowing NLRC5 transport towards the nucleus. The expression levels of NLRC5 and MHC class I are highly correlated, with more NLRC5 resulting in more MHC class I expression and increased MHC class I cell surface levels. NLRC5 is highly expressed in hematopoietic cells and tissues such as the spleen, lymph node, thymus, intestine, lung and bone marrow. NLRC5 is inducible by interferon-gamma (IFN-gamma). NLRC5 is decreased in tumor tissues of most cancer types. Lower NLRC5 expression is associated with reduced survival in melanoma, rectal, bladder, uterine, cervical and head/neck cancer.
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
Recognizes full-length mouse NLRC5. Does not cross-react with human NLRC5.
免疫原:
Recombinant mouse NLRC5 (CARD domain).
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
促销活动
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