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折扣/货期| 货号：AG-25T-0108-C100 | 规格：100 ug | 目录价：￥6360 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-PAG/Cbp, pAb (IG-452)
别名:
Phosphoprotein Associated with Glycosphingolipid-enriched Microdomains 1; Csk-binding Protein
产品描述:
PAG [Cbp] is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse band(s) of 80-90kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR (T cell antigen receptor)-mediated signaling in T cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. It inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins and may be involved in cell adhesion signaling.
宿主来源:
Rabbit
实验应用:
ICC, IP, WB
靶标/特异性:
Recognizes mouse, rat and human PAG/Cbp.
免疫原:
Synthetic peptide corresponding to aa 412-424 of the N-terminal rat PAG including an additional N-terminal Cys residue.
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 0.02% sodium azide.
产地:
瑞士
纯度:
Antigen affinity purified.
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